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Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmacological actions. We have assessed the protective action of GA on iron-induced neuronal cell damage by employing the PC12 cell line and primary culture of rat cortical neurons (PCRCN). A strong protection by GA, assessed by the 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carbox-anilide (XTT) assay, was revealed, with IC(50) values <1 mu M. GA also inhibited Fe(3+)-ascorbate reduction, iron-induced oxidative degradation of 2-deoxiribose, and iron-induced lipid peroxidation in rat brain homogenate, as well as stimulated oxygen consumption by Fe(2+) autoxidation. Absorption spectra and cyclic voltammograms of GA Fe(2+)/Fe(3+) com...
Increasing evidence suggests that iron plays an important role in tissue damage both during chronic ...
Background: there is an intimate relation between transition metals and cell homeostasis due to the ...
The development of different neurological disorders has been associated with the accumulation of rea...
Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharm...
The disruption of iron homeostasis is an important factor in the loss of mitochondrial function in n...
Artículo de publicación ISIThis work was aimed to test the hypothesis that sub-chronic administratio...
Iron (Fe) overload triggers free radical production and lipid peroxidation processes that may lead t...
Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with cytotoxic action in vi...
This work was aimed to test the hypothesis that sub-chronic administration of iron-dextran (Fe-dextr...
An in vivo model in rat was developed by intraperitoneally administration of Fe-dextran to study oxi...
The homeostasis of transition metal ions is central to many life processes, but the alterations in F...
Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superox...
Iron is an essential metal for almost all living organisms due to its involvement in a large number ...
Perineuronal nets (PNs) are a specialized form of extracellular matrix, surrounding different types ...
Mangiferin, a naturally occurring glucosylxanthone, has been described as having antidiabetic, antip...
Increasing evidence suggests that iron plays an important role in tissue damage both during chronic ...
Background: there is an intimate relation between transition metals and cell homeostasis due to the ...
The development of different neurological disorders has been associated with the accumulation of rea...
Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharm...
The disruption of iron homeostasis is an important factor in the loss of mitochondrial function in n...
Artículo de publicación ISIThis work was aimed to test the hypothesis that sub-chronic administratio...
Iron (Fe) overload triggers free radical production and lipid peroxidation processes that may lead t...
Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with cytotoxic action in vi...
This work was aimed to test the hypothesis that sub-chronic administration of iron-dextran (Fe-dextr...
An in vivo model in rat was developed by intraperitoneally administration of Fe-dextran to study oxi...
The homeostasis of transition metal ions is central to many life processes, but the alterations in F...
Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superox...
Iron is an essential metal for almost all living organisms due to its involvement in a large number ...
Perineuronal nets (PNs) are a specialized form of extracellular matrix, surrounding different types ...
Mangiferin, a naturally occurring glucosylxanthone, has been described as having antidiabetic, antip...
Increasing evidence suggests that iron plays an important role in tissue damage both during chronic ...
Background: there is an intimate relation between transition metals and cell homeostasis due to the ...
The development of different neurological disorders has been associated with the accumulation of rea...
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