Inhibition of microtubule function is an attractive rational approach to anticancer therapy. Although taxanes are the most prominent among the microtubule-stabilizers, their clinical toxicity, poor pharmacokinetic properties, and resistance have stimulated the search for new antitumor agents having the same mechanism of action. Discodermolide is an example of nontaxane natural product that has the same mechanism of action, demonstrating superior antitumor efficacy and therapeutic index. The extraordinary chemical and biological properties have qualified discodermolide as a lead structure for the design of novel anticancer agents with optimized therapeutic properties. In the present work, we have employed a specialized fragment-based method ...
Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used W...
Based on the conformer of paclitaxel extracted from the experimental tubulin structure, a pharmacoph...
Tubulin targeting agents constitute an important class of anticancer drugs. By acting either as micr...
Inhibition of microtubule function is an attractive rational approach to anticancer therapy. Althoug...
An important approach to cancer therapy is the design of small molecule modulators that interfere wi...
An important approach to cancer therapy is the design of small molecule modulators that interfere wi...
In 1990, the natural product discodermolide was isolated from a marine sponge and later found to hav...
AbstractBackground: During the past decade, Taxol has assumed an important role in cancer chemothera...
PHARMACOLOGICAL AND STRUCTURE-ACTIVITY RELATIONSHIP EVALUATION OF MICROTUBULE-STABILIZING AGENTSChar...
The remarkable therapeutic importance of taxane diterpenoids as anticancer drugs and their challengi...
(+)-Discodermolide, a C24:4, trihydroxylated, octamethyl, carbamate-bearing fatty acid lactone origi...
The antimitotic agent paclitaxel continues to play an important role in the cancer chemotherapy. How...
An efficient, convergent and stereocontrolled synthesis of simplified analogues of the potent antimi...
(+)-Discodermolide is a microtubule-stabilizing agent with potential for the treatment of taxol-refr...
41 p.-7 fig.-3 fig.-supl.The binding interactions of two antitumor agents that target the paclitaxel...
Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used W...
Based on the conformer of paclitaxel extracted from the experimental tubulin structure, a pharmacoph...
Tubulin targeting agents constitute an important class of anticancer drugs. By acting either as micr...
Inhibition of microtubule function is an attractive rational approach to anticancer therapy. Althoug...
An important approach to cancer therapy is the design of small molecule modulators that interfere wi...
An important approach to cancer therapy is the design of small molecule modulators that interfere wi...
In 1990, the natural product discodermolide was isolated from a marine sponge and later found to hav...
AbstractBackground: During the past decade, Taxol has assumed an important role in cancer chemothera...
PHARMACOLOGICAL AND STRUCTURE-ACTIVITY RELATIONSHIP EVALUATION OF MICROTUBULE-STABILIZING AGENTSChar...
The remarkable therapeutic importance of taxane diterpenoids as anticancer drugs and their challengi...
(+)-Discodermolide, a C24:4, trihydroxylated, octamethyl, carbamate-bearing fatty acid lactone origi...
The antimitotic agent paclitaxel continues to play an important role in the cancer chemotherapy. How...
An efficient, convergent and stereocontrolled synthesis of simplified analogues of the potent antimi...
(+)-Discodermolide is a microtubule-stabilizing agent with potential for the treatment of taxol-refr...
41 p.-7 fig.-3 fig.-supl.The binding interactions of two antitumor agents that target the paclitaxel...
Several novel analogues of (+)-discodermolide were synthesized via a convergent strategy that used W...
Based on the conformer of paclitaxel extracted from the experimental tubulin structure, a pharmacoph...
Tubulin targeting agents constitute an important class of anticancer drugs. By acting either as micr...