Expression of RANTES, eotaxin-2, ICAM-1, LFA-1 and CCR-3 in chronic rhinosinusitis patients with nasal polyposis
- Cavallari, Fransergio Emilio
- Pereira Valera, Fabiana Cardoso
- Gallego, Aline Jorge
- Malinsky, Rafael Rossell
- Kuepper, Daniel Salgado
- Milanezi, Cristiane
- da Silva, Joao Santana
- Tamashiro, Edwin
- Anselmo-Lima, Wilma Terezinha
Publication date
January 2012
DOI Publisher
ACTA CIRURGICA BRASILEIRA ISSN
0102-8650Abstract
PURPOSE: To compare gene expression of the chemokines RANTES and eotaxin-2, its receptor, CCR-3, adhesion molecule ICAM-1 and its receptor LFA-1 in eosinophilic polyps and in control normal nasal mucosa. METHODS: Gene expression was quantified by Real Time PCR in polyps (n=35) and in healthy nasal mucosa (n=15). RESULTS: Eosinophilic polyps showed a higher expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa. CONCLUSION: Eosinophilic polyps present greater expression of eotaxin-2 and RANTES, but not of CCR-3, ICAM-1 or LFA-1 compared to control nasal mucosa
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