Add to ORKGA hybrid material with excellent mechanical and biological properties is produced by electrospinning a co-solution of PET and collagen. The fibers are mapped using SEM, confocal Raman microscopy and collagenase digestion assays. Fibers of different compositions and morphologies are intermingled within the same membrane, resulting in a heterogeneous scaffold. The collagen distribution and exposure are found to depend on the PET/collagen ratio. The materials are chemically and mechanically characterized and biologically tested with fibroblasts (3T3-L1) and a HUVEC culture in vitro. All of the hybrid scaffolds show better cell attachment and proliferation than PET. These materials are potential candidates to be used as vascular grafts
Abstract One of the main challenges of tissue-engineered vascular prostheses is restenosis due to in...
To facilitate true regeneration, a vascular graft should direct the evolution of a neovessel to obta...
None of the replacements proposed in the literature for small-calibre blood vessels (SCBV) fully sat...
A hybrid material with excellent mechanical and biological properties is produced by electrospinning...
Suportes eletrofiados para crescimento celular são de interesse para a engenharia de tecidos, princi...
For small diameter (<6 mm) blood vessel replacements, lack of collaterals and vascular disease precl...
Aiming to develop a scaffold architecture mimicking morphological and mechanically that of a blood v...
Electrospun collagen alone does not provide the mechanical integrity necessary for tissue engineerin...
Significant challenges must be overcome before the true benefit and economic impact of vascular tiss...
Tissue-engineered vascular scaffolds provide a promising solution for the replacement of diseased va...
Next generation of biomaterials with enhanced functionalities requires the integration of material s...
AbstractA novel type of composite vascular graft was developed via electrospinning in the present in...
Cardiovascular diseases, including coronary artery and peripheral vascular pathologies, are leading ...
Abstract One of the main challenges of tissue-engineered vascular prostheses is restenosis due to in...
To facilitate true regeneration, a vascular graft should direct the evolution of a neovessel to obta...
None of the replacements proposed in the literature for small-calibre blood vessels (SCBV) fully sat...
A hybrid material with excellent mechanical and biological properties is produced by electrospinning...
Suportes eletrofiados para crescimento celular são de interesse para a engenharia de tecidos, princi...
For small diameter (<6 mm) blood vessel replacements, lack of collaterals and vascular disease precl...
Aiming to develop a scaffold architecture mimicking morphological and mechanically that of a blood v...
Electrospun collagen alone does not provide the mechanical integrity necessary for tissue engineerin...
Significant challenges must be overcome before the true benefit and economic impact of vascular tiss...
Tissue-engineered vascular scaffolds provide a promising solution for the replacement of diseased va...
Next generation of biomaterials with enhanced functionalities requires the integration of material s...
AbstractA novel type of composite vascular graft was developed via electrospinning in the present in...
Cardiovascular diseases, including coronary artery and peripheral vascular pathologies, are leading ...
Abstract One of the main challenges of tissue-engineered vascular prostheses is restenosis due to in...
To facilitate true regeneration, a vascular graft should direct the evolution of a neovessel to obta...
None of the replacements proposed in the literature for small-calibre blood vessels (SCBV) fully sat...