Translocation (8;21)(q22;q22)/RUNX1-RUNX1T1 is a molecular marker that is usually associated with a favorable outcome in both pediatric and adult patients with acute myeloid leukemia (AML). The present report describes the results of hematologic, cytogenetic, and fluorescence in situ hybridization analysis of a case of AML with maturation in a 23-year-old woman. Cytogenetic analysis revealed a balanced translocation involving chromosomal band 21q22, which disrupts the RUNX1 gene, and 10q22, with the following karyotype: 45,X,-X,t(10;21)(q24;q22)[cp16]/46,XX [4]. Interphase FISH showed, in 67% of the 300 interphase nuclei analyzed, three signals for RUNX1 and two RUNX1T1, but no signals corresponding to RUNX1-RUNX1T1 fusion gene. These resul...
Acute myeloid leukemia (AML) is characterized by a great cytogenetic and molecular genetic diversity...
The chromosome break points of the t(8;21)(q21.3;q22.12) translocation associated with acute myeloid...
The 8p11 myeloproliferative syndrome (EMS) is a chronic myeloproliferative disorder molecularly char...
Translocation (8;21)(q22;q22)/RUNX1-RUNX1T1 is a molecular marker that is usually associated with a ...
Reciprocal RUNX1 fusions are traditionally found in up to 10% of acute myeloid leukemia (AML) patien...
Reciprocal RUNX1 fusions are traditionally found in up to 10% of acute myeloid leukemia (AML) patien...
Acute myeloid leukemia (AML) represents a heterogeneous disease entity that is continuously moving t...
P>A proportion of cytogenetic abnormalities in myelodysplastic syndromes (MDS) and acute myeloid ...
The chromosome break points of the t(8;21)(q21.3;q22.12) translocation associated with acute myeloid...
Objectives: Core binding factor (CBF) leukemias represent an important prognostic group in acute mye...
Since the RUNX1 gene contributes to megakaryopoiesis and acquired trisomy 21 is the most frequent nu...
Aim. To evaluate the impact of additional chromosomal aberrations on outcomes of allogeneic hematopo...
We present a novel, rare but recurrent variant three way translocation of t(8;21), t(8;16;21)(q22;q2...
Translocation t(8;21)(q22;q22) is a common karyotypic abnormality detected in about 15% of acute mye...
Background. The RUNX1 (AML1) gene is a frequent mutational target in myelodysplastic syndromes and a...
Acute myeloid leukemia (AML) is characterized by a great cytogenetic and molecular genetic diversity...
The chromosome break points of the t(8;21)(q21.3;q22.12) translocation associated with acute myeloid...
The 8p11 myeloproliferative syndrome (EMS) is a chronic myeloproliferative disorder molecularly char...
Translocation (8;21)(q22;q22)/RUNX1-RUNX1T1 is a molecular marker that is usually associated with a ...
Reciprocal RUNX1 fusions are traditionally found in up to 10% of acute myeloid leukemia (AML) patien...
Reciprocal RUNX1 fusions are traditionally found in up to 10% of acute myeloid leukemia (AML) patien...
Acute myeloid leukemia (AML) represents a heterogeneous disease entity that is continuously moving t...
P>A proportion of cytogenetic abnormalities in myelodysplastic syndromes (MDS) and acute myeloid ...
The chromosome break points of the t(8;21)(q21.3;q22.12) translocation associated with acute myeloid...
Objectives: Core binding factor (CBF) leukemias represent an important prognostic group in acute mye...
Since the RUNX1 gene contributes to megakaryopoiesis and acquired trisomy 21 is the most frequent nu...
Aim. To evaluate the impact of additional chromosomal aberrations on outcomes of allogeneic hematopo...
We present a novel, rare but recurrent variant three way translocation of t(8;21), t(8;16;21)(q22;q2...
Translocation t(8;21)(q22;q22) is a common karyotypic abnormality detected in about 15% of acute mye...
Background. The RUNX1 (AML1) gene is a frequent mutational target in myelodysplastic syndromes and a...
Acute myeloid leukemia (AML) is characterized by a great cytogenetic and molecular genetic diversity...
The chromosome break points of the t(8;21)(q21.3;q22.12) translocation associated with acute myeloid...
The 8p11 myeloproliferative syndrome (EMS) is a chronic myeloproliferative disorder molecularly char...