Xeroderma pigmentosum patients suffer from extreme photosensitivity caused by a genetic defect in DNA repair pathways. This condition obliges them to live in darkness and avoid sunshine. Although the molecular basis of the defect has been known for more than 40 years now, the treatment possibilities are very limited, and to date all have been focused on the skin. Herein, we summarize the effects of sunlight and the molecular mechanisms implicated in the defects that lead to this syndrome, as well as the strategies that have been tested to alleviate skin manifestations, including cancer. Preclinical attempts to correct genetic defects by means of different gene therapy approaches are also described. All these efforts are now bringing hope an...
Xeroderma pigmentosum is a rare autosomal recessive disorder which is caused by germinal mutations r...
Xeroderma pigmentosum is a rare autosomal recessive disorder which is caused by germinal mutations r...
Xeroderma pigmentosum is a rare, autosomal recessive disease caused by a defect in DNA repair. Patie...
Xeroderma pigmentosum patients suffer from extreme photosensitivity caused by a genetic defect in DN...
Xeroderma pigmentosum patients suffer from extreme photosensitivity caused by a genetic defect in DN...
Abstract Xeroderma pigmentosum (XP) is defined by extreme sensitivity to sunlight, resulting in sunb...
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair. Affected individu...
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair characterized by su...
Xeroderma Pigmentosum (XP) is a rare genetic syndrome with a defective DNA nucleotide excision repai...
The repair of DNA damage by ultraviolet light is defective in the hereditary disease xeroderma pigme...
Background. Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV radiation-induce...
Background. Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV radiation-induce...
Xeroderma pigmentosum, Cockayne syndrome, the xeroderma pigmentosum-Cockayne syndrome complex, and t...
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair characterized by su...
Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder in which the ability to rep...
Xeroderma pigmentosum is a rare autosomal recessive disorder which is caused by germinal mutations r...
Xeroderma pigmentosum is a rare autosomal recessive disorder which is caused by germinal mutations r...
Xeroderma pigmentosum is a rare, autosomal recessive disease caused by a defect in DNA repair. Patie...
Xeroderma pigmentosum patients suffer from extreme photosensitivity caused by a genetic defect in DN...
Xeroderma pigmentosum patients suffer from extreme photosensitivity caused by a genetic defect in DN...
Abstract Xeroderma pigmentosum (XP) is defined by extreme sensitivity to sunlight, resulting in sunb...
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair. Affected individu...
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair characterized by su...
Xeroderma Pigmentosum (XP) is a rare genetic syndrome with a defective DNA nucleotide excision repai...
The repair of DNA damage by ultraviolet light is defective in the hereditary disease xeroderma pigme...
Background. Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV radiation-induce...
Background. Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV radiation-induce...
Xeroderma pigmentosum, Cockayne syndrome, the xeroderma pigmentosum-Cockayne syndrome complex, and t...
Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair characterized by su...
Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder in which the ability to rep...
Xeroderma pigmentosum is a rare autosomal recessive disorder which is caused by germinal mutations r...
Xeroderma pigmentosum is a rare autosomal recessive disorder which is caused by germinal mutations r...
Xeroderma pigmentosum is a rare, autosomal recessive disease caused by a defect in DNA repair. Patie...
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