Autologous Hematopoietic Stem Cell Transplantation for Type 1 Diabetes
- VOLTARELLI, Julio C.
- COURI, Carlos E. B.
- STRACIERI, Ana B. P. L.
- OLIVEIRA, Maria C.
- MORAES, Daniela A.
- PIERONI, Fabiano
- BARROS, George M. N.
- MADEIRA, Maria Isabel A.
- MALMEGRIM, Kelen C. R.
- FOSS-FREITAS, Maria C.
- SIMOES, Belinda P.
- FOSS, Milton C.
- SQUIERS, Elizabeth
- BURT, Richard K.
Publication date
January 2008
DOI Publisher
Foundation for Cellular and Molecular Medicine ISSN
0077-8923 Citation count (estimate)
26Abstract
In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirao Preto Medical School, University of Sao Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D
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