Add to ORKGWe examined the correlation between results obtained from the in vivo Draize test for ocular irritation and in vitro results obtained from the sheep red blood cell (RBC) haemolytic assay, which assesses haemolysis and protein denaturation in erythrocytes, induced by cosmetic products. We sought to validate the haemolytic assay as a preliminary test for identifying highly-irritative products, and also to evaluate the in vitro test as alternative assay for replacement of the in vivo test. In vitro and in vivo analyses were carried out on 19 cosmetic products, in order to correlate the lesions in the ocular structures with three in vitro parameters: (i) the extent of haemolysis (H50); (ii) the protein denaturation index (131); and (iii) the H5...
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a ...
Agrochemicals and veterinary products must undergo numerous toxicological tests before registration....
The 7th amendment of the EU Cosmetic Directive will lead to the ban of animal testing for cosmetic i...
We examined the correlation between results obtained from the in vivo Draize test for ocular irritat...
Em uma tentativa de construir as estratégias de avaliação para avaliar a irritação ocular humano, um...
Human eyes are frequently exposed to chemicals accidentally or on purpose due to their external loca...
Arginine-derivative surfactants constitute a novel class of surfactants, which can be regarded as an...
AbstractThe need for alternative approaches to replace the in vivo rabbit Draize eye test for evalua...
The assessment of ocular toxicity, (i.e., eye irritation and serious eye damage) is important to en...
In the last decades significant regulatory attempts were made to replace, refine and reduce animal t...
Current European legislations strongly call for alternatives to replace animal testing. In major eva...
In the last decades significant regulatory attempts were made to replace, refine and reduce animal t...
A national interlaboratory study to validate two alternative methods to the Draize rabbit's eye ...
There is a continual need for information concerning the potential for chemicals, if inadvertently s...
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a ...
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a ...
Agrochemicals and veterinary products must undergo numerous toxicological tests before registration....
The 7th amendment of the EU Cosmetic Directive will lead to the ban of animal testing for cosmetic i...
We examined the correlation between results obtained from the in vivo Draize test for ocular irritat...
Em uma tentativa de construir as estratégias de avaliação para avaliar a irritação ocular humano, um...
Human eyes are frequently exposed to chemicals accidentally or on purpose due to their external loca...
Arginine-derivative surfactants constitute a novel class of surfactants, which can be regarded as an...
AbstractThe need for alternative approaches to replace the in vivo rabbit Draize eye test for evalua...
The assessment of ocular toxicity, (i.e., eye irritation and serious eye damage) is important to en...
In the last decades significant regulatory attempts were made to replace, refine and reduce animal t...
Current European legislations strongly call for alternatives to replace animal testing. In major eva...
In the last decades significant regulatory attempts were made to replace, refine and reduce animal t...
A national interlaboratory study to validate two alternative methods to the Draize rabbit's eye ...
There is a continual need for information concerning the potential for chemicals, if inadvertently s...
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a ...
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a ...
Agrochemicals and veterinary products must undergo numerous toxicological tests before registration....
The 7th amendment of the EU Cosmetic Directive will lead to the ban of animal testing for cosmetic i...