Add to ORKGThis work was undertaken to provide further insight into the role of mammalian target of rapamycin complex 1 (mTORC1) in skeletal muscle regeneration, focusing on myofiber size recovery. Rats were treated or not with rapamycin, an mTORC1 inhibitor. Soleus muscles were then subjected to cryolesion and analyzed 1, 10, and 21 days later. A decrease in soleus myofiber cross-section area on post-cryolesion days 10 and 21 was accentuated by rapamycin, which was also effective in reducing protein synthesis in these freeze-injured muscles. The incidence of proliferating satellite cells during regeneration was unaltered by rapamycin, although immunolabeling for neonatal myosin heavy chain (MHC) was weaker in cryolesion+rapamycin muscles than in cryo...
SummaryMammalian target of rapamycin (mTOR) is a central controller of cell growth. mTOR assembles i...
The balance between protein synthesis and degradation (proteostasis) is a determining factor for mus...
104 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.To gain further insight into ...
This work was undertaken to provide further insight into the role of mammalian target of rapamycin c...
Background Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well estab...
Abstract Background The mammalian target of rapamycin complex 2 (mTORC2), containing the essential ...
Background: Skeletal muscle mass is determined by the balance between protein synthesis and degradat...
Skeletal muscle is composed of post-mitotic multinucleated myofibers. During embryonic skeletal myog...
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) has been well defined as an...
Rapamycin, a selective inhibitor of mTORC1 signaling, blocks terminal myoblast differentiation. We f...
International audienceThe present study was designed to test the hypothesis that increasing physical...
The mammalian target of rapamycin (mTOR) is a major regulator of skeletal myocyte viability. The sig...
The formation of multi-nucleated muscle fibers from progenitors requires the fine-tuned and coordina...
Myostatin (MSTN) is a well-known negative growth factor of muscle mass, and studies have shown that ...
There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associa...
SummaryMammalian target of rapamycin (mTOR) is a central controller of cell growth. mTOR assembles i...
The balance between protein synthesis and degradation (proteostasis) is a determining factor for mus...
104 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.To gain further insight into ...
This work was undertaken to provide further insight into the role of mammalian target of rapamycin c...
Background Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well estab...
Abstract Background The mammalian target of rapamycin complex 2 (mTORC2), containing the essential ...
Background: Skeletal muscle mass is determined by the balance between protein synthesis and degradat...
Skeletal muscle is composed of post-mitotic multinucleated myofibers. During embryonic skeletal myog...
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) has been well defined as an...
Rapamycin, a selective inhibitor of mTORC1 signaling, blocks terminal myoblast differentiation. We f...
International audienceThe present study was designed to test the hypothesis that increasing physical...
The mammalian target of rapamycin (mTOR) is a major regulator of skeletal myocyte viability. The sig...
The formation of multi-nucleated muscle fibers from progenitors requires the fine-tuned and coordina...
Myostatin (MSTN) is a well-known negative growth factor of muscle mass, and studies have shown that ...
There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associa...
SummaryMammalian target of rapamycin (mTOR) is a central controller of cell growth. mTOR assembles i...
The balance between protein synthesis and degradation (proteostasis) is a determining factor for mus...
104 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.To gain further insight into ...