Dengue hemorrhagic fever is associated with polymorphisms in JAK1
- Silva, Luciano Kalabric
- Blanton, Ronald Edward
- Parrado, Antonio R
- Melo, Paulo S
- Morato, Vanessa G
- Reis, Eliana Almeida Gomes
- Dias, Juarez Pereira
- Castro, Jesuina M
- Vasconcelos, Pedro F. C
- Goddard, Katrina A. B
- Barreto, Maurício Lima
- Reis, Mitermayer Galvão dos
- Teixeira, Glória
DOIAbstract
To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide polymorphisms (SNPs) in 56 genes across the type 1 interferon (IFN) response pathway as well as other important candidate genes. By single locus analysis comparing DHF with DF, 11 of the 51 markers with P<0.05 were in the JAK1 gene. Five markers were significantly associated by false discovery rate criteria (q<0.20 when P<6 × 10(-4)). The JAK1 SNPs showed differential distribution by ethnicity and ancestry consistent with epidemiologic observations in the Americas. The association remained significant after contr...
Add to ORKG