Hepatic pathology in Capillaria hepatica infected mice

A fibrose septal do f??gado se desenvolve regularmente em ratos infectados pela Capillaria hepatica. Com o fito de se verificar se tal tipo de fibrose tamb??m se desenvolve em camundongos, 20 animais foram infectados com 100 ou 300 ovos embrionados e examinados histologicamente em v??rios per??odos de tempo, entre 30 at?? 110 dias ap??s inocula????o. Os resultados demonstraram que os camundongos desenvolvem inicialmente uma intensa hepatite aguda, difusa e focal, mas logo estas les??es s??o moduladas, desaparecendo a hepatite reacional difusa e persistindo as les??es em torno de ovos e restos de vermes. Alguns poucos vermes sobreviveram por todo o per??odo experimental. Embora a fibrose perisinusoidal tenha aparecido em torno das les??es fibr??ticas focais, a fibrose septal n??o foi observada. N??o se sabe por que a fibrose septal se forma no rato infectado por C. hepatica, mas n??o no camundongo, mas o assunto merece investiga????o, pois importantes aspectos da fibrog??nese hep??tica poderiam estar implicados. Os camundongos parecem melhor adaptados ?? C. hepatica que os ratos; nos primeiros, a infec????o ?? nitidamente autolimitada.Septal fibrosis of the liver regularly develops in rats infected with Capillaria hepatica. To find out whether such fibrosis also occurs in mice, 20 animals were submitted to infection with either 100 or 300 embryonated eggs and histologically examined after several periods of time, from 30 to 110 days afterwards. Results showed that mice developed acute, severe, diffuse and focal hepatic lesions that were soon modulated to focal areas of fibrosis containing eggs and worm remnants, despite the fact that a few worms remained alive, at least up to 110 days after inoculation. Areas of perisinusoidal fibrosis appeared in the proximity and around focal parasitic lesions, but clear-cut septal fibrosis was not observed. Whey septal fibrosis forms in rats, but not in mice during C. hepatica infection, only further studies can clarify. Mice seem to show better host/parasite relationship than rats in regard to C. hepatica infection