Transmission of Streptococcus pneumoniae in an Urban Slum Community
- Reis, Joice Neves
- Palma, Tania
- Ribeiro, Guilherme de Sousa
- Pinheiro, Ricardo M.
- Ribeiro, Cássio Tâmara
- Cordeiro, Soraia Machado
- Silva Filho, Hermes Pedreira da
- Moschioni, Monica
- Thompson, Terry A
- Spratt, Brian G
- Riley, Lee Woodland
- Barocchi, Michele A
- Reis, Mitermayer Galvão dos
- Ko, Albert Icksang
DOIAbstract
Inhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries.We conducted a household survey of pneumococcal carriage among residents of a slum community in the city of Salvador, Brazil.Among 262 subjects, 95 (36%) were colonized with Streptococcus pneumoniae. Children <5 years of age (OR, 8.0; 95% CI, 3.5-18.6) and those who attended schools (OR, 2.7, 95% CI, 1.2-6.0) had significantly higher risk of being colonized. Of 94 isolates obtained from colonized individuals, 51% had serotypes included in the seven-valent pneumococcal conjugate vaccine. Overall, 10% (9 of 94 isolates) were nonsusceptible to penicillin and 28% (27 of 94 isolates) were resistant to cotr...
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