Pulmonary changes during acute experimental murine manson schistosomiasis

Recentemente tem sido observada a presen??a de tosse seca, dispn??ia, e manifesta????es de asma br??nquica em pacientes com esquistossomose aguda. Para se investigar sobre o tipo e patogenia de tais les??es foi utilizado um modelo experimental de esquistossomose aguda no camundongo. Quarenta animais foram divididos em quatro grupos de 10 animais cada, 3 infectados e um grupo controle n??o-infectados. Os exames foram feitos ap??s 7, 28-35, e 40 dias ap??s a exposi????o cercariana. Na fase aguda da infec????o (28-35 dias), encontrou-se um processo de pneumonite intersticial multifocal, envolvendo os tecidos peribr??nquicos, peribronquiolares e subpleural, processo que esteve ausente nas outras fases examinadas. N??o foi poss??vel a demonstra????o de ant??genos do Schistosoma. mansoni nas les??es da fase aguda, atrav??s da t??cnica de imuno-fluoresc??ncia indireta. A pneumonite foi atribu??da a produtos (mediadores inflamat??rios) gerados nas les??es hep??ticas necro-inflamat??rias periovulares da fase aguda, e transportados para os pulm??es pela circula????o sangu??nea.Dry cough, dyspnea and manifestations of bronchial asthma have recently been observed in patients with acute schistosomiasis. To investigate the type and pathogenesis of these conditions, an experimental mouse model for acute schistosomiasis was used. Forty mice were divided into four groups of ten each: three infected groups and a non-infected control group. The animals were examined 7, 28-35 and 40 days after exposure to cercariae. During the acute phase of the infection (28-35 days), a process of multifocal interstitial pneumonitis involving the peribronchial, peribronchiolar and subpleural tissues was found. This process was not seen during the other phases of the infection. Indirect immunofluorescence failed to demonstrate the presence of schistosomal antigens in the acute-phase lesions. The pneumonitis was attributed to products (inflammatory mediators) from acute-phase periovular necrotic-inflammatory lesions in the liver that were transported to the lungs by the bloodstream