PREVALENCE Hemoglobinopathies in newborns The municipality of Goiânia

As hemoglobinopatias são as desordens hereditárias mais comuns nos seres humanos, sendo as mais freqüentes as hemoglobinas S e C. O presente estudo avaliou a prevalência de hemoglobinopatias no Município de Goiânia através da análise da triagem neonatal, e comparou as prevalências de hemoglobinopatias entre a rede pública e privada. Amostras de sangue de 92.127 recém-nascidos foram analisadas. Um total de 61 recém-nascidos apresentaram hemoglobinopatia (7:10.000). Na rede pública e privada a prevalência foi de 7 e 3 por 10.000, respectivamente (p=0,081). Traço de hemoglobinopatia foi observado em 3.423 amostras (371:10.000); a rede pública com prevalência de 400:10.000 e a privada com 177:10.000 (p=0,0001). A doença falciforme teve prevalência de 4:10.000 nascimentos, sendo 5:10.000 na rede pública com e 2:10.000 na privada (p=0,133). Conclui-se que a doença falciforme apresenta alta prevalência e acomete crianças usuárias das redes pública e privada de saúde. A triagem neonatal é de extrema importância para a detecção precoce de pacientes com doença falciforme e de portadores assintomáticosHemoglobinopathies are the most common inherited disorders in humans; the most frequent are hemoglobins S and C. This study evaluates the prevalence of hemoglobin patterns at the city of Goiânia, state of Goiás, Brazil, using neonatal screennig. Prevalence was compared between exams from the public and private systems. Blood samples from 90,127 newborns were obtained. Hemoglobinopathies were identified in a total of 61 (7:10.000) newborns. The prevalence in public and private systems was 7 and 3 per 10,000 respectively (p=0.081). In 3,243 (371:10,000) hemoglobinopathy traits were detected. The public system´s prevalence was 400:10,000 and in the private system it was 177:10,000 (p=0.0001). The prevalence of sickle cell disease was 4.3:10,000 live birth overall; in the public system, it was 5:10,000 and in the private system it was 2:10,000 (p=0.133). We can conclude that sickle disease is of high prevalence in children at public and private systems. The neonatal screening information is of paramount importance for early diagnosis of sickle disease and people with sickle trait