Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa

A otite externa ?? a inflama????o do conduto auditivo externo, com etiologia infecciosa ou n??o. Casos de neglig??ncia fazem com que ocorram recidivas, dificultando tratamento e elevando a resist??ncia microbiana aos m??todos convencionais, tornando assim as plantas medicinais uma alternativa. O Triticum aestivum (trigo), j?? demonstrou a????o antioxidante, anti-inflamat??rio, antimicrobiano, hepatoprotetor e cicatrizante. O Rosmarinus officinalis L. (alecrim) possui propriedades medicinais como antimicrobiano, anti-inflamat??rio, analg??sico, antimutag??nico, diur??tico, expectorante e antioxidante. Neste contexto, objetivou-se avaliar a utiliza????o dos extratos aquosos de trigo e alecrim e ??leo essencial de alecrim no tratamento da otite externa infecciosa experimental. A otite externa foi induzida em 64 ratos Wistar atrav??s da instila????o de ??leo de cr??ton 5% em acetona em conjunto com Staphylococcus aureus no conduto auditivo dos animais. Os tratamentos foram divididos em extrato aquoso de trigo 25% em propilenoglicol (GI), extrato aquoso de alecrim 25% em propilenoglicol (GII), ??leo essencial de alecrim 5% em propilenoglicol (GIII), propilenoglicol (GIV) e solu????o fisiol??gica (GV). Os animais foram tratados por at?? sete dias e realizadas an??lises macrosc??picas aos quatro, seis e dez dias atrav??s do m??todo de Emg??rd & Hellstr??m para colora????o, di??metro, efus??o, al??m da an??lise histopatol??gica, em quatro animais por grupo. Foram observados resultados promissores com o extrato aquoso de trigo (GI), e extrato aquoso de alecrim (GII), sendo capazes de reduzir os par??metros cl??nicos macrosc??picos, assim como os par??metros histopatol??gicos. Nas condi????es experimentais deste trabalho, a concentra????o utilizada de ??leo essencial n??o foi efetiva. Assim, demonstrou-se que os extratos aquosos de trigo e alecrim a 25% em propilenoglicol promovem a acelera????o da resolu????o da otite externa infecciosa.External otitis is an inflammation of the outer ear and ear canal, which may or may not be of infectious cause. Negligence will lead to recurrence, hampering treatment and causing bacterial resistance to conventional methodologies. In this context, medicinal plants and plant extracts may be an alternative. Triticum aestivum (wheat) has been shown to act as an antioxidant, anti-inflammatory, pain-killer, as well as used in wound healing. Rosmarinus officinalis L. (rosemary) has antibacterial, anti-inflammatory, pain-killer, anti-mutagenic, diuretic, expectorant, and antioxidant effects. In this context, the objective of this study was to assess the use of wheat and rosemary aqueous extracts, and rosemary essential oil, in the treatment of infectious external otitis. Experimental otitis was induced in rats Wistar with croton oil at 5% in acetone, followed by the introduction of Staphylococcus aureus in the outer ear canal. Animals were separated according to the treatment group: GI 25% wheat aqueous extract in propylene glycol; GII 25% rosemary aqueous extract in propylene glycol; GIII 5% rosemary essential oil in propylene glycol; GIV propylene glycol; and GV saline. The animals were treated for up to seven days, and assessed regarding clinical (according to the Emgard & Hellstr??m method) and hitopathological alterations, on days four, six and ten. Promising results were observed on animals treated with both aqueous extracts, primarily in GI (wheat), but also in GII (rosemary), both were able to reduce clinical and histopathological parameters beyond the effect of the control. This study shows that the aqueous extract of both T. aestivum and R. oficinallis promoted the hastening of the healing process of infectious external otitis