Magnetic particles as analytical tool in medicine

This work reports on knowledge of magnetic nanoparticles, modification of their surface and their using in different areas. Literature review describes using MNPs in separation techniques of analytic biochemistry to imobilizate nucleic acids and proteins. The matter of experimental part is synthesis of MNPs using coprecipitation of iron salts and next modification of their surface. In MNPs preparation the effect of the presence of PEG in the reaction mixture and the temperature effect on the resulting properties of MNPs was examined. MNPs surface was modified by two different methods, emulsion polymerization method with precursors MMA and AAc, and carboxylation method using 11 -mercaptoundecanoic acid. PEG or temperature had little effect on the properties of the prepared MNPs. Establishing carboxyl groups succeeded only when the method of emulsion polymerization was used