Izolace a charakterizace nového antimikrobiálního peptidu (defenzinu) exprimovaného v klíštěti obecném \kur{Ixodes ricinus}

Ticks are important blood feeding arthropod vectors of different pathogens. Control of tick-borne pathogens is complicated due to a lack of vaccines. Development of the novel methods of tick control and search of the new vaccine candidates are required for suppression of tick populations and for control of tick-borne infectious diseases. Among possible candidates, defensins are espicially interesting. In this study, a novel anionic Ixodes ricinus defensin named AnIrDef is described, and its antimicrobial activity in vitro is confirmed. Due to the similarity with defensins from other ticks, it is assumed that I. ricinus AnIrDef is involved in the defence against microbes from bloodmeals