We have developed a mathematical model of the rabbit atrial myocyte in order to investigate the ionic bases of rate dependent changes in action potential (AP) wave-shape. Postulated mediators of such changes include rate dependencies of ionic currents (incomplete reactivation) and ionic concentration gradients. The model utilizes biophysical data to quantify the specific morphology and electrophysiology of the rabbit atrial cell. Ionic current descriptions incorporate whole-cell voltage-clamp data from enzymatically isolated rabbit cardiomyocytes, and account for the reactivation timecourse of the largest ionic currents. Our model can simulate both the whole-cell voltage-clamp data upon which it is based and the steady-state AP wave-shapes ...
The system of transverse and longitudinal sarcolemmal tubules (T-system) is observed to remodel in a...
Atrial fibrillation (AF) is a complex, multifaceted arrhythmia. Pathogenesis of AF is associated wit...
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. ...
Mathematical models of rabbit atrial and ventricular myocytes that are based on quantitative voltage...
We have developed a mathematical model of the human atrial myocyte, based on averaged voltage-clamp ...
[EN] Several mathematical models of rabbit ventricular action potential (AP) have been proposed to i...
[EN] Several mathematical models of rabbit ventricular action potential (AP) have been proposed to i...
Atrial fibrillation is the most prevalent arrhythmia, but the mechanisms by which it develops are no...
Computational models for cardiomyocyte action potentials (AP) often make use of a large parameter se...
AbstractMathematical modeling of the cardiac action potential has proven to be a powerful tool for i...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
Intracellular action potentials were recorded from rabbit heart sinoatrial node (SAN) and atrial int...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
The system of transverse and longitudinal sarcolemmal tubules (T-system) is observed to remodel in a...
Atrial fibrillation (AF) is a complex, multifaceted arrhythmia. Pathogenesis of AF is associated wit...
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. ...
Mathematical models of rabbit atrial and ventricular myocytes that are based on quantitative voltage...
We have developed a mathematical model of the human atrial myocyte, based on averaged voltage-clamp ...
[EN] Several mathematical models of rabbit ventricular action potential (AP) have been proposed to i...
[EN] Several mathematical models of rabbit ventricular action potential (AP) have been proposed to i...
Atrial fibrillation is the most prevalent arrhythmia, but the mechanisms by which it develops are no...
Computational models for cardiomyocyte action potentials (AP) often make use of a large parameter se...
AbstractMathematical modeling of the cardiac action potential has proven to be a powerful tool for i...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
Intracellular action potentials were recorded from rabbit heart sinoatrial node (SAN) and atrial int...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
Models of cardiac electrophysiology are widely used to supplement experimental results and to provid...
The system of transverse and longitudinal sarcolemmal tubules (T-system) is observed to remodel in a...
Atrial fibrillation (AF) is a complex, multifaceted arrhythmia. Pathogenesis of AF is associated wit...
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice. ...