Statistical and biophysical modeling of binaural interaction in the lateral superior olive

The Lateral Superior Olive (LSO) is believed to be involved in encoding high frequency localization information based on interaural level difference (ILD) and interaural time difference (ITD) cues. Details of how this information is encoded remain uncertain. This work develops a biophysical model of the LSO network capable of simulating LSO responses to acoustically realistic stimuli. Our LSO network simulations demonstrate the extreme sensitivity of the LSO transient response to time delays caused by both ILDs and ITDs. This sensitivity to delay suggests a possible encoding role for the LSO transient