Add to ORKGSynthetic studies on ecteinascidin 743 (b), an antitumor antibiotic, are described. The key reactions include: (1) an acylimmium ion-mediated stereoselective construction of the optically pure diazobicyclo (3.3.1) nonane nucleus 6, (2) a stereocontrolled Pictet-Spengler cyclization for the formation of tetrahydroisoquinoline 2, and (3) the attempted benzylic oxidation of the pentacyclic phenol 22.(DIAGRAM, TABLE OR GRAPHIC OMITTED...PLEASE SEE DAI
The development of modern pharmaceuticals relies heavily upon the drug discovery process to uncover ...
This dissertation concerns the stereoselective synthesis of optically pure compound 196, the C₁₆-C₃₂...
Aigialomycin D is a fungal natural product possessing kinase inhibition properties. It is a member o...
A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid E...
This thesis consists of five sections. The first four discuss chemistry that is relevant to a total ...
A synthetic route via the key intermediate DX-52-1 21 has resulted in the first total synthesis of t...
The thesis is composed of three chapters. The aim of this thesis is to apply the novel dirhodium per...
The Saframycins are naturally occurring antibiotics with an interesting bisquinone structure. The fi...
The following dissertation describes a collection of results that led to a successful formal total s...
A novel synthetic route via iterative condensations of piperazinedione and substituted benzaldehydes...
Chapter 1 discusses the asymmetric synthesis of (3S)-hexahydropyridazine-3-carboxylic acid [(3S)-pip...
A strategy is outlined for construction of the fungal immunosuppressant FR901483 (1). It was possibl...
In 1970 art article was published in the Journal of Antibiotics in which the isolation of a substanc...
abstract: The ecteinascidins are a family of tetrahydroisoquinoline alkaloids isolated from the tuni...
A novel approach for the synthesis of antitumor agents Discorhabdins (1) is described. The synthetic...
The development of modern pharmaceuticals relies heavily upon the drug discovery process to uncover ...
This dissertation concerns the stereoselective synthesis of optically pure compound 196, the C₁₆-C₃₂...
Aigialomycin D is a fungal natural product possessing kinase inhibition properties. It is a member o...
A practical and an efficient synthesis of three building blocks of tetrahydroisoquinoline alkaloid E...
This thesis consists of five sections. The first four discuss chemistry that is relevant to a total ...
A synthetic route via the key intermediate DX-52-1 21 has resulted in the first total synthesis of t...
The thesis is composed of three chapters. The aim of this thesis is to apply the novel dirhodium per...
The Saframycins are naturally occurring antibiotics with an interesting bisquinone structure. The fi...
The following dissertation describes a collection of results that led to a successful formal total s...
A novel synthetic route via iterative condensations of piperazinedione and substituted benzaldehydes...
Chapter 1 discusses the asymmetric synthesis of (3S)-hexahydropyridazine-3-carboxylic acid [(3S)-pip...
A strategy is outlined for construction of the fungal immunosuppressant FR901483 (1). It was possibl...
In 1970 art article was published in the Journal of Antibiotics in which the isolation of a substanc...
abstract: The ecteinascidins are a family of tetrahydroisoquinoline alkaloids isolated from the tuni...
A novel approach for the synthesis of antitumor agents Discorhabdins (1) is described. The synthetic...
The development of modern pharmaceuticals relies heavily upon the drug discovery process to uncover ...
This dissertation concerns the stereoselective synthesis of optically pure compound 196, the C₁₆-C₃₂...
Aigialomycin D is a fungal natural product possessing kinase inhibition properties. It is a member o...