Fat, fibre and cancer risk in African Americans and rural Africans
- O'Keefe, S.J.
- Li, J.V.
- Lahti, Leo
- Ou, J.
- Carbonero, F.
- Khaled, M.
- Postma, J.M.
- Kinross, J.
- Wahl, E.
- Ruder, E.
- Vipperla, K.
- Naidoo, V.
- Mtshali, L.
- Tims, S.
- Puylaert, P.G.B.
- DeLany, J.
- Krasinskas, A.
- Benefiel, A.C.
- Kaseb, H.O.
- Newton, K.
- Nicholson, J.K.
- Vos, W.M., De
- Gaskins, H.R.
- Zoetendal, E.G.
DOIAbstract
Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, th...
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