Outdoor airborne transmission of coronavirus among apartments in high-density cities

The coronaviruses have inflicted health and societal crises in recent decades. Both SARS CoV-1 and 2 are suspected to spread through outdoor routes in high-density cities, infecting residents in apartments on separate floors or in different buildings in many superspreading events, often in the absence of close personal contact. The viability of such mode of transmission is disputed in the research literature, and there is little evidence on the dose–response relationship at the apartment level. This paper describes a study to examine the viability of outdoor airborne transmission between neighboring apartments in high density cities. A first-principles model, airborne transmission via outdoor route (ATOR), was developed to simulate airborne pathogen generation, natural decay, outdoor dispersion, apartment entry, and inhalation exposure of susceptible persons in neighboring apartments. The model was partially evaluated using a smoke tracer experiment in a mock-up high-density city site and cross-checking using the computational fluid dynamics (CFD) models. The ATOR model was used to retrospectively investigate the relationship between viral exposure and disease infection at an apartment level in two superspreading events in Hong Kong: the SARS outbreak in Amoy Gardens and the COVID-19 outbreak in Luk Chuen House. Logistic regression results suggested that the predicted viral exposure was positively correlated with the probability of disease infection at apartment level for both events. Infection risks associated with the outdoor route transmission of SARS can be reduced to