Since the early 20th century, the illegal drug trade has been of increasing focus throughout the world. However, the use of mind-altering substances predates attempts to prohibit or regulate them. Early control efforts date back to the teachings of Mohammed in the Koran, though wider-scale control efforts did not occur until the 18th century. Since that time, the control of illicit drugs has been commonplace throughout the world. Several illicit markets exist in responding to the ongoing demand. Four notable ones are cocaine, heroin, cannabis, and synthetically-produced, mind-altering substances. The production, transportation, and usage of these substances are all impacted by the histories of the producer, intermediary, and user countries....