Brain glutamate levels and antipsychotic response in schizophrenia
- Egerton, Alice
- Merritt, Kate
- McQueen, Grant
- Howes, Oliver
- Demjaha, Arsime
- Brugger, Stefan
- Barker, Gareth
- Stone, James
- Dazzan, Paola
- Broberg, Brian
- van Haren, Neeltje
- Glenthoj, Birte
- Kahn, Rene
- McGuire, Philip
DOIAbstract
Background: There is considerable interest in identifying biomarkers of antipsychotic response in schizophrenia, and brain glutamate is one key candidate. Methods: In a series of 1H-MRS studies, we have investigated the relationship between brain glutamate and antipsychotic response. This includes cross-sectional studies in patients with early psychosis,1 and chronic schizophrenia.2,3 Longitudinally, within the OPTiMiSE consortium, we examined whether glutamate levels in first-episode psychosis (FEP; n = 72, <2 weeks antipsychotic medication) predict psychopathology after subsequent administration of oral amisulpride for 4 weeks. Finally, in an ongoing study in treatment-resistant schizophrenia, we investigate whether glutamate levels pr...
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