Starting from the definition of fractional M/M/1 queue given in the reference by Cahoy et al. in 2015 and M/M/1 queue with catastrophes given in the reference by Di Crescenzo et al. in 2003, we define and study a fractional M/M/1 queue with catastrophes. In particular, we focus our attention on the transient behaviour, in which the time-change plays a key role. We first specify the conditions for the global uniqueness of solutions of the corresponding linear fractional differential problem. Then, we provide an alternative expression for the transient distribution of the fractional M/M/1 model, the state probabilities for the fractional queue with catastrophes, the distributions of the busy period for fractional queues without and with catas...