A series of 1′-(6-aminopurin-9-yl)-1′-deoxy-N-methyl-β-D-ribofuranuronamides that were characterised by 2-dialkylamino-7-methyloxazolo[4,5-b]pyridin-5-ylmethyl substituents on N6 of interest for screening as selective adenosine A3 receptor agonists, have been synthesised. This work involved the synthesis of 2-dialkylamino-5-aminomethyl-7-methyloxazolo[4,5-b]pyridines and analogues that were coupled with the known 1′-(6-chloropurin-9-yl)-1′-deoxy-N-methyl-β-D-ribofuranuronamide. The oxazolo[4,5-b]pyridines were synthesized by regioselective functionalisation of 2,4-dimethylpyridine N-oxides. The regioselectivities of these reactions were found to depend upon the nature of the heterocycle with 2-dimethylamino-5,7-dimethyloxazolo[4,5-b]pyridin...
Adenosine (Ado) is an endogenous nucleoside ubiquitous in mammals promoting protection and cells rep...
A new series of 2-aralkynyl-N6-methyl-MECAs 10-13 were synthesized and evaluated in radioligand bind...
A new series of 1-deoxy-1-[(6-(4-(substituted-aminosulfonyl)phenyl)amino)carbonylamino-9H-purin-9-yl...
The aim of this work was the design and synthesis of new A2A and A3 adenosine receptors antagonists....
A new series of 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide-bearing N-arylureas...
Adenosine (Ado) is involved in the regulation of many physiological and pathophysiological processes...
New A3 adenosine receptor antagonists I [R1 = HO(CH2)2, (EtO)2CHCH2, HO2CCH2, etc.; R2 = H, PhNHCO, ...
A series of ring-constrained (N)-methanocarba-5′-uronamide 2,N6-disubstituted adenine nucleosides ha...
International audienceThe synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave as...
A new series of 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide++ ...
A new series of 2-aralkynyl-N6-methyl-MECAs 10-13 were synthesized and evaluated in radioligand bind...
A number of derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine (5) were synthesized and biologica...
Adenosine receptors (ARs) trigger signal transduction pathways inside the cell when activated by ext...
Adenosine (Ado) is an endogenous nucleoside ubiquitous in mammals promoting protection and cells rep...
A new series of 2-aralkynyl-N6-methyl-MECAs 10-13 were synthesized and evaluated in radioligand bind...
A new series of 1-deoxy-1-[(6-(4-(substituted-aminosulfonyl)phenyl)amino)carbonylamino-9H-purin-9-yl...
The aim of this work was the design and synthesis of new A2A and A3 adenosine receptors antagonists....
A new series of 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide-bearing N-arylureas...
Adenosine (Ado) is involved in the regulation of many physiological and pathophysiological processes...
New A3 adenosine receptor antagonists I [R1 = HO(CH2)2, (EtO)2CHCH2, HO2CCH2, etc.; R2 = H, PhNHCO, ...
A series of ring-constrained (N)-methanocarba-5′-uronamide 2,N6-disubstituted adenine nucleosides ha...
International audienceThe synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave as...
A new series of 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide++ ...
A new series of 2-aralkynyl-N6-methyl-MECAs 10-13 were synthesized and evaluated in radioligand bind...
A number of derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine (5) were synthesized and biologica...
Adenosine receptors (ARs) trigger signal transduction pathways inside the cell when activated by ext...
Adenosine (Ado) is an endogenous nucleoside ubiquitous in mammals promoting protection and cells rep...
A new series of 2-aralkynyl-N6-methyl-MECAs 10-13 were synthesized and evaluated in radioligand bind...
A new series of 1-deoxy-1-[(6-(4-(substituted-aminosulfonyl)phenyl)amino)carbonylamino-9H-purin-9-yl...