Eicosanoids are important mediators of fever, pain and inflammation that modulate cell signaling during acute and chronic disease. We show using lipidomics, that thrombin-activated human platelets generate a new type of eicosanoid which both stimulates and primes human neutrophil integrin (Mac-1) expression, in response to fMLP . Detailed characterization supports a dioxolane (DX) structure, 8-hydroxy-9,11-dioxolane eicosatriaenoic acid (dioxolane A3, DXA3). The lipid is generated in ng amounts by platelets from endogenous arachidonate during physiological activation, with inhibition by aspirin in vitro or in vivo, implicating cyclooxygenase-1 (COX). Pharmacological and genetic studies on human/murine platelets revealed that DXA3 formation ...
Human platelets lack 5-lipoxygenase activity, but possess enzymatic capacity to transformthe unstabl...
Platelet aggregation and thrombosis are critical processes in hemostasis and wound healing, but thei...
In addition to haemostasis, platelets are involved in pathological processes, often driven by materi...
Eicosanoids are important mediators of fever, pain and inflammation that modulate cell signaling dur...
This research was originally published in the Journal of Biological Chemistry. .Hinz C, et al. Human...
Platelet-derived eicosanoids play important signalling roles in haemostasis and innate immunity and ...
Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA3). Herein...
Eicosanoids are critical mediators of fever, pain, and inflammation generated by immune and tissue c...
Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in ...
Initially, prostaglandins (PGs) were considered to only exist as free acid mediators. Although, form...
Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive ...
Human platelets lack 5-lipoxygenase activity, but possess enzymatic capacity to transformthe unstabl...
Platelet aggregation and thrombosis are critical processes in hemostasis and wound healing, but thei...
In addition to haemostasis, platelets are involved in pathological processes, often driven by materi...
Eicosanoids are important mediators of fever, pain and inflammation that modulate cell signaling dur...
This research was originally published in the Journal of Biological Chemistry. .Hinz C, et al. Human...
Platelet-derived eicosanoids play important signalling roles in haemostasis and innate immunity and ...
Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA3). Herein...
Eicosanoids are critical mediators of fever, pain, and inflammation generated by immune and tissue c...
Oxidized phospholipids (oxPLs) generated nonenzymatically display pleiotropic biological actions in ...
Initially, prostaglandins (PGs) were considered to only exist as free acid mediators. Although, form...
Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive ...
Human platelets lack 5-lipoxygenase activity, but possess enzymatic capacity to transformthe unstabl...
Platelet aggregation and thrombosis are critical processes in hemostasis and wound healing, but thei...
In addition to haemostasis, platelets are involved in pathological processes, often driven by materi...