The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis
AbstractAlthough widely explored, the pathogenesis of Alzheimer’s disease (AD) has yet to be cleared...
Alzheimer's disease threatens to become the scourge of the 21st century. Hundreds of millions of agi...
Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate clinical ...
© 2014 Morris et al.; licensee BioMed Central Ltd. The amyloid hypothesis has driven drug developmen...
The conventional view of AD (Alzheimer’s disease) is that much of the pathology is driven by an incr...
Alzheimer's disease (AD) is a biologically complex neurodegenerative dementia. Nearly 20 years ago, ...
This scientific commentary refers to ‘Atrophy, hypometabolism and clinical trajectories in patients ...
The first description of Alzheimer's disease (AD) was made in 1907 by Alois Alzheimer (Allgemeine Ze...
The 'amyloid cascade hypothesis' (ACH) is the most influential model of the pathogenesis of Alzheime...
International audienceThe amyloid cascade hypothesis (ACH) has dominated contemporary biomedical res...
Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are...
Fil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordina...
The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or fibrillar am...
The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide in the bra...
In these last years, several phase III randomized controlled trials testing promising candidates sha...
AbstractAlthough widely explored, the pathogenesis of Alzheimer’s disease (AD) has yet to be cleared...
Alzheimer's disease threatens to become the scourge of the 21st century. Hundreds of millions of agi...
Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate clinical ...
© 2014 Morris et al.; licensee BioMed Central Ltd. The amyloid hypothesis has driven drug developmen...
The conventional view of AD (Alzheimer’s disease) is that much of the pathology is driven by an incr...
Alzheimer's disease (AD) is a biologically complex neurodegenerative dementia. Nearly 20 years ago, ...
This scientific commentary refers to ‘Atrophy, hypometabolism and clinical trajectories in patients ...
The first description of Alzheimer's disease (AD) was made in 1907 by Alois Alzheimer (Allgemeine Ze...
The 'amyloid cascade hypothesis' (ACH) is the most influential model of the pathogenesis of Alzheime...
International audienceThe amyloid cascade hypothesis (ACH) has dominated contemporary biomedical res...
Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are...
Fil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordina...
The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or fibrillar am...
The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide in the bra...
In these last years, several phase III randomized controlled trials testing promising candidates sha...
AbstractAlthough widely explored, the pathogenesis of Alzheimer’s disease (AD) has yet to be cleared...
Alzheimer's disease threatens to become the scourge of the 21st century. Hundreds of millions of agi...
Many drugs that target amyloid-β (Aβ) in Alzheimer disease (AD) have failed to demonstrate clinical ...
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