Validity of a clinical model to predict influenza in patients presenting with symptoms of lower respiratory tract infection in primary care

van Vugt, Saskia F
Broekhuizen, Berna DL
Zuithoff, Nicolaas PA
van Essen, Gerrit A
Ebell, Mark H
Coenen, Samuel
Ieven, Margareta
Lammens, Christine
Goossens, Herman
Butler, Christopher Collett
Hood, Kerenza
Little, Paul
Verheij, Theo JM

Publication date

August 2015

DOI

10.1093/fampra/cmv039

Publisher

Oxford University Press (OUP)

Abstract

Background. Valid clinical predictors of influenza in patients presenting with lower respiratory tract infection (LRTI) symptoms would provide adequate patient information and reassurance. Aim. Assessing the validity of an existing diagnostic model (Flu Score) to detect influenza in LRTI patients. Design and Setting. A European diagnostic study recruited 1801 adult primary care patients with LRTI-like symptoms existing ≤7 days between October and April 2007–2010. Method. History and physical examination findings were recorded and nasopharyngeal swabs taken. Polymerase chain reaction (PCR) for influenza A/B was performed as reference test. Diagnostic accuracy of the Flu Score (1× onset <48 hours + 2× myalgia + 1× chills or sweats + ...