P-glycoprotein is an ATPase binding cassette (ABC) drug-transporter protein represented by MDR1 in humans and mdr1a and mdr1b in mice. The substrate specificity of this protein is unusually large due to the polyspecific nature of its binding pocket and as a result a wide range of endogenous and exogenous compounds are effluxed by this transporter. There is a large body of literature about the role of P-glycoprotein in limiting the absorption of drug substrates at a number of barriers but currently data in the lung is limited. P-gp expression and localisation studies have confirmed its presence in lung tissue but there is conflicting data with regards to the functional relevance on lung absorption. The aims of this project were to es...
abstract: Measurements of different molecular species from single cells have the potential to reveal...
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polym...
Planaria have been used for decades as subjects for psychopharmacology research, predominantly in ad...
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of dea...
This study looked at the potential use of supine gas transfer measurements using carbon monoxide and...
Ion transport across cellular membranes is essential for the viability of all organisms. This includ...
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of dea...
Cholangiocarcinoma (CCA) has a high mortality rate and its occurrence is rising. This increase promp...
OBJECTIVES: To compare the effect of repetitive low-threshhold afferent electrical stimulation of t...
The following PhD project regards the field of the drug delivery systems. In particular, the aim of ...
This study investigated the effects of environmental toxicants on the immune system of two pinniped ...
IDEX Health and Science has created a thin-film composite membrane consisting of a carbon nanotube m...
We encounter thousands of species of fungi each day, only a few of these are pathogenic to humans an...
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polym...
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polym...
abstract: Measurements of different molecular species from single cells have the potential to reveal...
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polym...
Planaria have been used for decades as subjects for psychopharmacology research, predominantly in ad...
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of dea...
This study looked at the potential use of supine gas transfer measurements using carbon monoxide and...
Ion transport across cellular membranes is essential for the viability of all organisms. This includ...
End-stage lung disease due to chronic obstructive pulmonary disease (COPD) is a leading cause of dea...
Cholangiocarcinoma (CCA) has a high mortality rate and its occurrence is rising. This increase promp...
OBJECTIVES: To compare the effect of repetitive low-threshhold afferent electrical stimulation of t...
The following PhD project regards the field of the drug delivery systems. In particular, the aim of ...
This study investigated the effects of environmental toxicants on the immune system of two pinniped ...
IDEX Health and Science has created a thin-film composite membrane consisting of a carbon nanotube m...
We encounter thousands of species of fungi each day, only a few of these are pathogenic to humans an...
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polym...
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polym...
abstract: Measurements of different molecular species from single cells have the potential to reveal...
Polymer crystallization is a classical problem of polymer research. Many synthetic and natural polym...
Planaria have been used for decades as subjects for psychopharmacology research, predominantly in ad...