Neurodegenerative diseases of Guam: analysis of TAU
- Perez-Tur, J.
- Buee, L.
- Morris, Huw
- Waring, S. C.
- Onstead, L.
- Wavrant-De Vrieze, F.
- Crook, R.
- Buee-Scherrer, V.
- Hof, P. R.
- Peterson, R. C.
- McGeer, P. L.
- Delacourte, A.
- Hutton, M.
- Siddique, T.
- Ahlskog, J. E.
- Hardy, J.
- Steele, J. C.
Publication date
July 1999
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
Mutations in the tau gene have been described in families affected by frontotemporal dementia with parkinsonism linked to chromosome 17. The authors performed a genetic and biochemical analysis of this gene and its product in the parkinsonism dementia complex of Guam, a disorder characterized by the extensive formation of neurofibrillary tangles. The tau gene is not a primary cause of the parkinsonism dementia complex of Guam
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