Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties
- Bertrand, Benoit
- Stefan, Loic
- Pirrotta, Marc
- Monchaud, David
- Bodio, Ewen
- Richard, Philippe
- Le Gendre, Pierre
- Warmerdam, Elena
- de Jager, Marina H.
- Groothuis, Geny M. M.
- Picquet, Michel
- Casini, Angela
DOIAbstract
Organometallic Au(I) NHC compounds bearing caffeine-type ligands have been synthesized and characterized as promising anticancer agents. The bis-carbene complex [Au(caffeine-2-yliene)2][BF4] appeared to be selective for human ovarian cancer cell lines in vitro and poorly toxic in healthy organs ex vivo. The compound shows high affinity and selectivity for G-quadruplex structures as demonstrated by FRET melting assay
Add to ORKG