Objective: To assess the 1-year safety profile of the dopaminergic stabilizer pridopidine in patients with Huntington disease. Methods: Patients received pridopidine 45 mg/day for 4 weeks then pridopidine 90 mg/day for 22 weeks in this 6-month open-label extension (OLE) of the 6-month MermaiHD randomized controlled trial (RCT). Any adverse events (AEs) were recorded. Patients were categorized by their RCT treatment group (placebo, pridopidine 45 mg/day, pridopidine 90 mg/day). Results: Of the 386 patients who completed the RCT, 353 entered the OLE and 305 (86.4%) completed. In 1 year, similar percentages of patients from each group reported ≥1 AE (placebo, 79.6% [n = 90/113]; 45 mg/day, 80.8% [n = 101/125]; 90 mg/day, 82.6% [n = 95/11...
Contains fulltext : 51751.pdf (publisher's version ) (Closed access)OBJECTIVE: We ...
Aripiprazole (AP), a dopamine (DA) D2 receptor partial agonist, has recently been used to reduce sch...
International audienceBACKGROUND: Cysteamine has been demonstrated as potentially effective in numer...
Objective: To assess the 1-year safety profile of the dopaminergic stabilizer pridopidine in patient...
Background: Previous trials have shown that pridopidine might reduce motor impairment in patients wi...
OBJECTIVES:: To evaluate the efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) ...
© 2019 Elsevier Ltd Background: Previous trials have shown that pridopidine might reduce motor impai...
We examined the effects of 3 dosages of pridopidine, a dopamine-stabilizing compound, on motor funct...
Ferdinando Squitieri,1 Justo Garcia de Yebenes2 1IRCCS Casa Sollievo della Sofferenza, San Giovanni...
OBJECTIVES: Alterations in dopamine neurotransmission underlie some of the clinical features of Hunt...
Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder leading to...
Objectives: Alterations in dopamine neurotransmission underlie some of the clinical features of Hunt...
OBJECTIVE To assess the anti-choreatic efficacy, safety and tolerability of AFQ056 in Huntington’s...
Background This study investigated the hypothesis that AFQ056 (mavoglurant), a selective metabotrop...
IMPORTANCE: Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metab...
Contains fulltext : 51751.pdf (publisher's version ) (Closed access)OBJECTIVE: We ...
Aripiprazole (AP), a dopamine (DA) D2 receptor partial agonist, has recently been used to reduce sch...
International audienceBACKGROUND: Cysteamine has been demonstrated as potentially effective in numer...
Objective: To assess the 1-year safety profile of the dopaminergic stabilizer pridopidine in patient...
Background: Previous trials have shown that pridopidine might reduce motor impairment in patients wi...
OBJECTIVES:: To evaluate the efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) ...
© 2019 Elsevier Ltd Background: Previous trials have shown that pridopidine might reduce motor impai...
We examined the effects of 3 dosages of pridopidine, a dopamine-stabilizing compound, on motor funct...
Ferdinando Squitieri,1 Justo Garcia de Yebenes2 1IRCCS Casa Sollievo della Sofferenza, San Giovanni...
OBJECTIVES: Alterations in dopamine neurotransmission underlie some of the clinical features of Hunt...
Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder leading to...
Objectives: Alterations in dopamine neurotransmission underlie some of the clinical features of Hunt...
OBJECTIVE To assess the anti-choreatic efficacy, safety and tolerability of AFQ056 in Huntington’s...
Background This study investigated the hypothesis that AFQ056 (mavoglurant), a selective metabotrop...
IMPORTANCE: Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metab...
Contains fulltext : 51751.pdf (publisher's version ) (Closed access)OBJECTIVE: We ...
Aripiprazole (AP), a dopamine (DA) D2 receptor partial agonist, has recently been used to reduce sch...
International audienceBACKGROUND: Cysteamine has been demonstrated as potentially effective in numer...