Synthesis of 2,4-disubstituted piperidines via radical cyclization: Unexpected enhancement in diastereoselectivity with tris(trimethylsilyl) silane

Gandon, Lucile A.
Russell, Alexander G.
Guveli, Tatyana
Brodwolf, Angela E.
Kariuki, Benson
Spencer, Neil
Snaith, John S.

Publication date

July 2006

DOI

10.1021/jo060495w

Publisher

American Chemical Society (ACS)

Abstract

A novel approach to 2,4-disubstituted piperidines involves the radical cyclization of 7-substituted-6-aza-8-bromooct-2-enoates. An enhancement in diastereoselectivity using tris(trimethylsilyl)silane instead of tributyltin hydride is discussed

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Synthesis of 2,4-disubstituted piperidines via radical cyclization: Unexpected enhancement in diastereoselectivity with tris(trimethylsilyl) silane

Abstract

Extracted data

Synthesis of 2,4-disubstituted piperidines via radical cyclization: Unexpected enhancement in diastereoselectivity with tris(trimethylsilyl) silane

Abstract

Extracted data

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