We consider an open string version of the topological twist previously proposed for sigma-models with G2 target spaces. We determine the cohomology of open strings states and relate these to geometric deformations of calibrated submanifolds and to flat or anti-self-dual connections on such submanifolds. On associative three-cycles we show that the worldvolume theory is a gauge-fixed Chern-Simons theory coupled to normal deformations of the cycle. For coassociative four-cycles we find a functional that extremizes on anti-self-dual gauge fields. A brane wrapping the whole G2 induces a seven-dimensional associative Chern-Simons theory on the manifold. This theory has already been proposed by Donaldson and Thomas as the higher-dimensional gener...