CD8 controls T cell cross-reactivity
- Wooldridge, Linda
- Laugel, Bruno Frederic
- Ekeruche, Julia
- Clement, Mathew
- van den Berg, Hugo A.
- Price, David
- Sewell, Andrew K.
DOIAbstract
Estimates of human αβ TCR diversity suggest that there are <108 different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the pMHC. In this study, we show that the CD8 coreceptor controls T cell cross-reactivity for pMHCI Ags, thereby ensuring that the peripheral T cell repertoire is optimally poised to negotiate the competing demands of responsiveness in the face of danger ...
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