In the central nervous system Na+-dependent glutamate transporters bind extracellular glutamate and transport it into cells surrounding the synapse, terminating excitatory signals. These glutamate transporters also function as ion channels. The glutamate transporter, GLAST-1, is expressed in the plasma membrane of osteoblasts and osteocytes and is the same molecular weight as in brain. Thus in bone cells GLAST-1 may transport glutamate or operate as a glutamate gated ion channel. A splice variant, GLAST-1a, is also expressed in bone. Hydropathy and Western blot analysis suggest GLAST-1a adopts a reversed orientation within the cell membrane. Sodium and potassium ion gradients drive glutamate transport but glycosylation, oxidation and phosph...
The cellular mechanisms coupling mechanical loading with bone remodeling remain unclear. In the CNS,...
Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt t...
Bone relies on multiple extracellular signalling systems to maintain homeostasis of its normal struc...
In the central nervous system Na+-dependent glutamate transporters bind extracellular glutamate and ...
The glutamate/aspartate transporter GLAST-1 is expressed in bone in vivo and also exists as a splice...
The amino acid L-glutamate mediates signals at excitatory synapses in the CNS where its effects are ...
AbstractPreviously we have reported expression of an mRNA with homology to the Na+-dependent glutama...
Without habitual exercise, bone is lost from the skeleton. Interactions between the effects of loadi...
Previously we have reported expression of an mRNA with homology to the Na+-dependent glutamate trans...
Development and function of osteoblast lineage cells are regulated by a complex microenvironment con...
Mechanical loading of the skeleton is important for maintenance of adequate bone mass and defined me...
Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt t...
Osteoclasts are involved in the catabolism of the bone matrix and eliminate the resulting degradatio...
The cellular mechanisms coupling mechanical loading with bone remodeling remain unclear. In the CNS,...
Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt t...
Bone relies on multiple extracellular signalling systems to maintain homeostasis of its normal struc...
In the central nervous system Na+-dependent glutamate transporters bind extracellular glutamate and ...
The glutamate/aspartate transporter GLAST-1 is expressed in bone in vivo and also exists as a splice...
The amino acid L-glutamate mediates signals at excitatory synapses in the CNS where its effects are ...
AbstractPreviously we have reported expression of an mRNA with homology to the Na+-dependent glutama...
Without habitual exercise, bone is lost from the skeleton. Interactions between the effects of loadi...
Previously we have reported expression of an mRNA with homology to the Na+-dependent glutamate trans...
Development and function of osteoblast lineage cells are regulated by a complex microenvironment con...
Mechanical loading of the skeleton is important for maintenance of adequate bone mass and defined me...
Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt t...
Osteoclasts are involved in the catabolism of the bone matrix and eliminate the resulting degradatio...
The cellular mechanisms coupling mechanical loading with bone remodeling remain unclear. In the CNS,...
Mechanical loading plays a key role in the physiology of bone, allowing bone to functionally adapt t...
Bone relies on multiple extracellular signalling systems to maintain homeostasis of its normal struc...