A form of programmed cell death, necroptosis, in intestinal epithelial cells initiates mucosal inflammation. A study now finds that prostanoid EP4 receptor signalling interferes with RIPK1/RIPK3-dependent MLKL activation, thereby inhibiting necroptosis and accelerating resolution of inflammation
Aim: The aim of the present study was to determine the expression level of receptor-interacting prot...
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial response...
Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in hum...
tBackground: Necroptosis is an inflammatory form of programmed cell death requiring receptor-interac...
Crohn's disease (CD) and ulcerative colitis (UC) are common intestinal bowel diseases (IBD) characte...
Introduction: Necroptosis is a newly discovered form of regulated cell death that occurs when apopto...
Inflammatory bowel diseases (IBD) are chronic inflammatory processes that affect the gastrointestina...
Background and aimsTumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic targ...
Cell death mechanisms have been associated with the development of inflammatory bowel diseases in hu...
Receptor interacting protein kinase 1 (RIPK1) has an essential role in the signalling triggered by d...
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cel...
Cell proliferation and cell death are integral elements in maintaining homeostatic balance in metazo...
Necroptosis is a caspases-independent programmed cell death displaying intermediate features between...
Postoperative multi-organ dysfunction (MOD) is associated with significant mortality and morbidity. ...
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, t...
Aim: The aim of the present study was to determine the expression level of receptor-interacting prot...
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial response...
Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in hum...
tBackground: Necroptosis is an inflammatory form of programmed cell death requiring receptor-interac...
Crohn's disease (CD) and ulcerative colitis (UC) are common intestinal bowel diseases (IBD) characte...
Introduction: Necroptosis is a newly discovered form of regulated cell death that occurs when apopto...
Inflammatory bowel diseases (IBD) are chronic inflammatory processes that affect the gastrointestina...
Background and aimsTumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic targ...
Cell death mechanisms have been associated with the development of inflammatory bowel diseases in hu...
Receptor interacting protein kinase 1 (RIPK1) has an essential role in the signalling triggered by d...
Chronic inflammatory disorders are characterised by aberrant and exaggerated inflammatory immune cel...
Cell proliferation and cell death are integral elements in maintaining homeostatic balance in metazo...
Necroptosis is a caspases-independent programmed cell death displaying intermediate features between...
Postoperative multi-organ dysfunction (MOD) is associated with significant mortality and morbidity. ...
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, t...
Aim: The aim of the present study was to determine the expression level of receptor-interacting prot...
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial response...
Mitogen-activated protein kinases (MAPK) are among the major widespread transduction pathways in hum...
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