Protein S-nitrosation on cysteine residues has emerged as an important posttranslational modification in mammalian cells. Previous studies have suggested a primary role for thioredoxin (Trx) in controlling protein S-nitrosation reactions. Human Trx contains five conserved Cys, including two redox-active catalytic Cys (Cys32 and Cys35) and three non-active-site Cys (Cys62, Cys69, and Cys73), all of which have been reported as targets of S-nitrosation. Prior reports have studied thermodynamic end points of nitrosation reactions; however, the kinetics of Trx nitrosation has not previously been investigated. Using the transnitrosation agent, S-nitrosoglutathione, a kinetic analysis of the selectivity and redox dependence of Trx nitrosation at p...
Mammalian thioredoxin reductases (TRs) are central enzymes in the thioredoxin (Trx) redox pathway. T...
Background: S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
<p>S-nitrosylation, the prototypic mechanism of redox-based signal transduction, involves the covale...
Transnitrosylation and denitrosylation are emerging as key post-translational modification events in...
Nitric oxide (NO) is a free radical with a signaling capacity. Its cellular functions are achieved m...
S-nitrosylation (or S-nitrosation) has emerged as an important pathway of non-classical nitric oxide...
The homeostasis of intracellular redox status has a crucial role in the cell survival and different ...
S-nitrosylation of proteins occurs as a consequence of the derivatization of cysteine thiols with ni...
Thioredoxin (Trx) and thioredoxin reductase (TrxR) plus NADPH, comprising the thioredoxin system, ha...
The aim of the present study was to define the role of Trx and Grx on metabolic thiol redox regulati...
ABSTRACT: High-molecular mass thioredoxin reductases (TRs) are pyridine nucleotide disulfide oxidore...
AbstractThe human redox protein thioredoxin is an autocrine growth factor for some cancer cells. Red...
BACKGROUND: S-nitrosation--the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins...
BACKGROUND. S-nitrosation - the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
Oxidative stress involves the increased production and accumulation of free radicals, peroxides, and...
Mammalian thioredoxin reductases (TRs) are central enzymes in the thioredoxin (Trx) redox pathway. T...
Background: S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
<p>S-nitrosylation, the prototypic mechanism of redox-based signal transduction, involves the covale...
Transnitrosylation and denitrosylation are emerging as key post-translational modification events in...
Nitric oxide (NO) is a free radical with a signaling capacity. Its cellular functions are achieved m...
S-nitrosylation (or S-nitrosation) has emerged as an important pathway of non-classical nitric oxide...
The homeostasis of intracellular redox status has a crucial role in the cell survival and different ...
S-nitrosylation of proteins occurs as a consequence of the derivatization of cysteine thiols with ni...
Thioredoxin (Trx) and thioredoxin reductase (TrxR) plus NADPH, comprising the thioredoxin system, ha...
The aim of the present study was to define the role of Trx and Grx on metabolic thiol redox regulati...
ABSTRACT: High-molecular mass thioredoxin reductases (TRs) are pyridine nucleotide disulfide oxidore...
AbstractThe human redox protein thioredoxin is an autocrine growth factor for some cancer cells. Red...
BACKGROUND: S-nitrosation--the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins...
BACKGROUND. S-nitrosation - the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
Oxidative stress involves the increased production and accumulation of free radicals, peroxides, and...
Mammalian thioredoxin reductases (TRs) are central enzymes in the thioredoxin (Trx) redox pathway. T...
Background: S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in protein...
<p>S-nitrosylation, the prototypic mechanism of redox-based signal transduction, involves the covale...