Background: Rhodopsin, the prototypic member of G protein-coupled receptors (GPCRs), undergoes isomerization of 11- cis-retinal to all-trans-retinal upon photoactivation. Although the basic mechanism by which rhodopsin is activated is well understood, the roles of whole transmembrane (TM) helix-III during rhodopsin photoactivation in detail are not completely clear. Principal Findings: We herein use single-cysteine mutagenesis technique to investigate conformational changes in TM helices of rhodopsin upon photoactivation. Specifically, we study changes in accessibility and reactivity of cysteine residues introduced into the TM helix-III of rhodopsin. Twenty-eight single-cysteine mutants of rhodopsin (P107C-R135C) were prepared after substi...
G protein coupled receptors (GPCRs) are membrane proteins with many functional roles. This family of...
AbstractLight activated rhodopsin interacts with domains on all three subunits of transducin. Two of...
AbstractRhodopsin, the dim-light photoreceptor present in the rod cells of the retina, is both a ret...
Rhodopsin, the prototypic member of G protein-coupled receptors (GPCRs), undergoes isomerization of ...
Rhodopsin, the prototypic member of G protein-coupled receptors (GPCRs), undergoes isomerization of ...
SummaryThe signal-transduction mechanism of rhodopsin was studied by molecular dynamics (MD) simulat...
The 11-cis retinal chromophore is tightly packed within the interior of the visual receptor rhodopsi...
The cytoplasmic surface of the G-protein coupled receptor (GPCR) rhodopsin is a key element in membr...
AbstractRhodopsin, a prototypical G protein-coupled receptor, catalyzes the activation of a heterotr...
AbstractAs one of the best studied members of the pharmaceutically relevant family of G-protein-coup...
The disruption of ionic and H-bond interactions between the cytosolic ends of transmembrane helices ...
AbstractDisruption of an interhelical salt bridge between the retinal protonated Schiff base linked ...
The cytoplasmic loops of rhodopsin, the rod cell photoreceptor, play important regulatory roles in t...
Rhodopsin is the visual photoreceptor responsible for dim light vision. This receptor is located in ...
AbstractRetinal cis-trans isomerization and early relaxation steps have been studied in a 10-ns mole...
G protein coupled receptors (GPCRs) are membrane proteins with many functional roles. This family of...
AbstractLight activated rhodopsin interacts with domains on all three subunits of transducin. Two of...
AbstractRhodopsin, the dim-light photoreceptor present in the rod cells of the retina, is both a ret...
Rhodopsin, the prototypic member of G protein-coupled receptors (GPCRs), undergoes isomerization of ...
Rhodopsin, the prototypic member of G protein-coupled receptors (GPCRs), undergoes isomerization of ...
SummaryThe signal-transduction mechanism of rhodopsin was studied by molecular dynamics (MD) simulat...
The 11-cis retinal chromophore is tightly packed within the interior of the visual receptor rhodopsi...
The cytoplasmic surface of the G-protein coupled receptor (GPCR) rhodopsin is a key element in membr...
AbstractRhodopsin, a prototypical G protein-coupled receptor, catalyzes the activation of a heterotr...
AbstractAs one of the best studied members of the pharmaceutically relevant family of G-protein-coup...
The disruption of ionic and H-bond interactions between the cytosolic ends of transmembrane helices ...
AbstractDisruption of an interhelical salt bridge between the retinal protonated Schiff base linked ...
The cytoplasmic loops of rhodopsin, the rod cell photoreceptor, play important regulatory roles in t...
Rhodopsin is the visual photoreceptor responsible for dim light vision. This receptor is located in ...
AbstractRetinal cis-trans isomerization and early relaxation steps have been studied in a 10-ns mole...
G protein coupled receptors (GPCRs) are membrane proteins with many functional roles. This family of...
AbstractLight activated rhodopsin interacts with domains on all three subunits of transducin. Two of...
AbstractRhodopsin, the dim-light photoreceptor present in the rod cells of the retina, is both a ret...