A number of naturally occurring, proton-rich nuclides (the p-nuclei) cannot be made in the s- and r-process. It has been found that massive stars can produce p-nuclei through photodisintegration of pre-existing intermediate and heavy nuclei. This so-called gamma-process requires sufficiently high temperatures and occurs in pre-explosive or explosive O/Ne burning, depending on the mass of the star. Although the gamma-process has been successful in producing a large range of p-nuclei, two mass regions remain problematic, A<110 and 150<A<165, where a number of p-nuclei are severely underproduced. The origin of the problems is yet to be identified. A large number of unstable nuclei with only theoretically predicted reaction rates are included i...