In vivo remodeling of fibroblast-derived vascular scaffolds implanted for 6 months in rats
- Tondreau, Maxime
- Laterreur, Véronique
- Germain, Lucie
- Vallières, Karine
- Ruel, Jean
- Tremblay, Catherine
- Bourget, Jean-Michel
- Auger, François A.
- Gauvin, Robert
- Lacroix, Dan.
DOIAbstract
There is a clinical need for tissue-engineered small-diameter (<6 mm) vascular grafts since clinical applications are halted by the limited suitability of autologous or synthetic grafts. This study uses the self-assembly approach to produce a fibroblast-derived decellularized vascular scaffold (FDVS) that can be available off-the-shelf. Briefly, extracellular matrix scaffolds were produced using human dermal fibroblasts sheets rolled around a mandrel, maintained in culture to allow for the formation of cohesive and three-dimensional tubular constructs, and decellularized by immersion in deionized water. The FDVSs were implanted as an aortic interpositional graft in six Sprague-Dawley rats for 6 months. Five out of the six implants were stil...
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