Age aspects of acute myocardial infarction

Aim. To study the clinical and laboratory features of patients with acute myocardial infarction with ST segment elevation (STEMI) depending on age. Materials and methods. Included 150 people diagnosed with STEMI in the first day of the disease. Clinical, laboratory features of patients were studied. In the dynamics of inpatient treatment, with hospitalization (visit 1) and discharge (visit 2), indicators of the N-terminal prostatic natriuretic peptide (NTproBNP) and growth differentiation factor 15 (GFD-15) were evaluated. Results. The average age of patients with STEMI was 61.7±2.9 years. The age-related clinical and laboratory features of the course of STEMI are described. With comparable hemodynamic data, markers of myocardial necrosis in patients with STEMI with age, a statistically significant increase in the level of NTproBNP and GFD-15 was detected. An increase in GDF-15 levels in patients over 60 years old >1200 ng/ml identifies a high risk of recurrent myocardial infarction. In the dynamics of inpatient treatment of patients with STEMI up to 75 years, a decrease in laboratory parameters NTproBNP and GFD-15 was revealed. The NTproBNP indicator has a positive correlation with the functional class of chronic heart failure (r=0.20, p<0.04), the GRACE scale (r=0.38, p