Mesoporous silica-supported Pt catalysts in enantioselective hydrogenation of ethyl pyruvate

Catalytic properties of Pt catalysts supported on mesoporous silica (Pt/m-SiO2) have been studied in enantioselective hydrogenation of ethyl pyruvate. The influences of pore structure of mesoporous silica (m-SiO2), type of chiral modifier, and H2 pressure on the catalytic performance have been investigated by using various m-SiO2 supports and cinchona alkaloids and by varying H2 pressure. The use of MCM-41, SBA-15, KIT-6, and MCF reveals that characteristic pore structure and size of m-SiO2 supports significantly affect both activity and enantioselectivity. A facile diffusion of chiral modifier through large mesopores of MCF support enables Pt/MCF to exhibit excellent performance. A comparison of the efficiency of cinchona alkaloids-modified Pt catalysts shows that QN and QD lead to higher performance than CD and CN at ambient H2 pressure. The influence of cinchona alkaloids on enantioselectivity noticeably depends on H2 pressure. Cinchona alkaloid-modified Pt/m-SiO2 exhibit superior enantioselectivity to the corresponding Pt/Al2O3 under various H2 pressures. These results imply that m-SiO2 is a promising support and that fine control of pore structure can further improve catalytic performance of Pt/m-SiO2 in heterogeneous enantioselective hydrogenation. © 2020 Elsevier B.V.11Nsciescopu