Investigation of Anti-Angiogenesis Properties of Cerium Oxide Nanoparticles Synthesized by Green Method from Persicaria bistorta Plant

Background and Objectives: Nanoparticles have a wide range of applications, such as environmental, pharmaceutical, nutritional, diagnostic and therapeutic, cosmetics, agricultural, energy, textile, and electronics applications. This study aimed to investigate the anti-angiogenesis properties of cerium oxide nanoparticles synthesized by green method from Persicaria bistorta Plant. Angiogenesis refers to the process of formation of new blood vessels from pre-existing blood vessels, which is important for the normal growth and development of the body. Persicaria bistorta is a perennial plant that its height is slightly less than 1 m and in some areas is very short and up to 20 cm. One of the distinct characteristics of the plant is its thick underground stem that is cylindral clinging and its outer surface is covered by a lot of beads with medicinal uses. Methods: In this study, chick chorioallantoic membrane was treated with cerium oxide nanoparticles synthesized by green method from Persicaria bistorta plant (CAM test). Comparison of the results in the groups, was performed by SPSS software. Results: The obtained data showed that the number and length of the vessels formed during 12 days after the treatment with nanoparticles significantly decreased. Conclusion: Cerium oxide nanoparticles synthesized by green method from Persicaria bistorta plan can be effective in the treatment of angiogenesis-related diseases, including cancer, through reduction of the angiogenesis process