The problem of making predictions from theories that have landscapes of possible low energy parameters is reviewed. Conditions for such a theory to yield falsifiable predictions for doable experiments are given. It is shown that the hypothesis of cosmological natural selection satisfies these conditions, thus showing that it is possible to continue to do physics on a landscape without invoking the anthropic principle. In particular, this is true whether or not the ensemble of universes generated by black holes bouncing is a sub-ensemble of a larger ensemble that might be generated by a random process such as eternal inflation. A recent criticism of cosmological natural selection made by Vilenkin in hep-th/0610051 is discussed. It is shown t...