POSSIBILITIES OF USE OF IMMUNE MODULATORS IN COMPLEX THERAPY OF COMMUNITY-ACQUIRED PNEUMONIAS

Community-acquired pneumonia (CAP) has been one the most pressing issues of healthcare due to high morbidity and mortality that are stable. Analysis of literature shows similar trends in the character of immune response of patients with CAP, precisely - formation of immune response via humoral route (Th2) with suppression of cell immune response (Thl), whereas lack of cellular and humoral mechanisms of immunity and dysbalanced cytokine portion determine severity of the infection course. Inclusion of immune modulators into traditional therapy allows to enhance the response to the therapy already being administered. One of the national immune modulators is azoximer bromide (polyoxidonium), its administration allows to reduce the length and severity of the disease, as well as reduce the frequency of development of prolonged forms. Also, immune modulators of bacterial origin have received special interest as of late, and antibacterial therapeutic vaccines are being constructed based on them. Immunovac VP-4 polycomponent vaccine is distinguishable among the national preparations. Clinical-immunological effect of the vaccine has been studied in recent years on different pathologies and methods of administration in adults and children. Features of Immunovac VP-4 effect confirm the primary character of alterations in the immune system, that is the background of a certain pathology and is the reason for inclusion of immune modulating preparations into basic therapy of the diseases