Correlation of immunoglobulin E and its microelement composition in mixed saliva in children through the stages of orthodontic treatment using base materials

Lab-diagnostic methods have been employed to study immunoglobulin E and microelements in the non-stimulated oral liquid in children aged 4,5 yrs - 8 yrs using removable orthodontic appliances. It has been shown that an appropriate index of correlation connection between the immune system stress and the level of microelements is the growth of the copper/zinc ratio gradient in case of increasing concentration of iron and tungsten in the mixed saliva. It has been proven there is a need for conducting allergen-specific immune-modifying therapy to bring to normal the humoral immunity factors in order to improve the anti-microbial protection of the oral cavity