OXIDIZING STRESS ANTIOXIDANT THERAPY IN PREGRAVIDAR TRAINING AND/OR INFERTILITY

Over the past few decades the incidence of infertility and sub-fertility has increased significantly, particularly in developed countries. External environmental factors, such as air and soil pollution, contact with different chemicals, are consdiered as the cause of both female and male fertility decline. Various lifestyle factors, such as nutrition, chronic diseases, stress, allergies, smoking and alcohol consumption, are also seen as potential causes of fertility decline.The toxic effects of various harmful substances on a reproductive human system can lead to a disruption of the synthesis of steroid hormones, as well as to the direct damage to the tissue of reproductive organs. It is known that the main pathological mechanism for the negative effects of toxic substances on reproduction is the development of oxidized stress, an important component of various serious human diseases.Antioxidants are a group of medications that neutralize the free radicals. Antioxidants include various vitamins, minerals, as well as polyunsaturated fatty acids. Various antioxidants (in the form of biologically active additives) and multivitamins are often indicated as preconception training for women and men who are planning a natural pregnancy and are experiencing a fertility problem or patients in the preparation for the program of auxiliary reproductive technologies (ART). The purpose of the drugs is to increase fertility and increase the effectiveness of the ART program, but the efficacy of such therapy has not been definitively defined.This literature review provides the up-to-date literature data on the effects of vitamin A, C, E, omega-3-polyunsaturated fatty acids, melatonin and the Q10 coenzyme on various aspects of the human reproduction function