Metformin is the most recognized first choice drug for patients with type 2 diabetes mellitus

Many anti-diabetic drugs are now available to treat type 2 diabetes mellitus, including sulfonylureas, glinides, α-glucosidase inhibitors, thiazolidinediones, incretin-related drugs, glucagon-like peptide-1 (GLP-1) analogues, sodium-glucose co-transporter 2 (SGLT2) inhibitors and, certainly, metformin. It holds a central position, given its role in reducing hyperglycemia and the risk of life-threatening complications. The International Diabetes Federation annually confirms the appropriateness of the appointment of metformin as a first step in the treatment of type 2 diabetes mellitus along with lifestyle modification [1]